Nuclear receptors link gender dimorphism of renal disease progression.

Profound gender differences in the progression of chronic kidney disease (CKD) remain poorly understood. Differential expression of the genes for male- and female-specific proteins in the kidney has been proposed to account for this clinical phenomenon. Lu and colleagues provide evidence that the signaling pathways of the nuclear receptors ERalpha, AR and PPARalpha are associated with gender differences in CKD progression.