AI Article Synopsis
- * We used hierarchical clustering to analyze these genes in relation to specific genetic profiles (HLA-DRB1/DQB1) of the individuals.
- * The clustering revealed three distinct groups based on genetic susceptibility, indicating that the major histocompatibility complex (MHC) may play a significant role in understanding gene expression in diabetes.
Article Abstract
We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HLA)-DRB1/DQB1 profile. The dendrogram obtained using the Cluster program grouped patients and controls into three clusters, one including individuals with no susceptibility alleles, another including individuals with at least three susceptibility alleles, and a third intermingling susceptibility/protective alleles. In addition to other variables, the results of the present article suggest that the major histocompatibility complex (MHC) class II profile may be of relevance for the study of a large-scale differentially expressed genes.
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| http://dx.doi.org/10.1196/annals.1375.046 | DOI Listing |
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