Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/01443610600994767 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases.
Mol Med
December 2024
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Article Synopsis
- - The study explores the potential of chlorquinaldol (CQ), an antimicrobial agent, as a specific inhibitor of the NLRP3 inflammasome, which is linked to various inflammatory diseases, highlighting its promise for drug repurposing.
- - CQ effectively suppresses NLRP3 inflammasome activation in both mouse and human macrophages primarily by blocking the interaction between NLRP3 and ASC, while having minimal impact on other inflammasomes like NLRC4 and AIM2.
- - In vivo tests showed that CQ significantly improves conditions in mouse models of LPS-induced peritonitis, DSS-induced colitis, and MSU-induced gouty arthritis, suggesting its therapeutic potential for treating NLRP3-related
Sonic vibration ameliorates inflammatory diseases via the up-regulation of IL-10.
Anim Cells Syst (Seoul)
April 2024
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
Sonic vibration (SV), or vibroacoustic therapy, is applied to enhance local and systemic blood circulation and alleviate pain using low-frequency sine wave vibrations. However, there is limited scientific data on the mechanisms through which the benefits are achieved. In this study, we investigated the impact of SV on inflammatory responses by assessing cytokine secretion in both and models.
View Article and Find Full Text PDFUltrasensitive near-infrared electrochemiluminescence biosensor derived from Eu-MOF with antenna effect and high efficiency catalysis of specific CoS hollow triple shelled nanoboxes for procalcitonin.
Biosens Bioelectron
November 2021
Collaborative Innovation Centre for Green Chemical Manufacturing and Accurate Detection School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, Shandong, China; Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, Shandong, China.
In this paper, we report a novel multiple amplification strategy for ultrasensitive near-infrared electrochemiluminescence (ECL) immunoassay in KSO solution. The realization of this strategy is based on the antenna effect of Eu-MOF (EuBTC) and a high efficiency catalysis of CoS hollow triple shelled nanoboxes (TSNBs). The HBTC ligand in the antenna effect first undergoes π-π* absorption and a singlet-singlet electronic transition.
View Article and Find Full Text PDFSynthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33).
Pharmaceuticals (Basel)
May 2021
Laboratory of Immunobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Street, 53-114 Wroclaw, Poland.
Previous studies demonstrated strong anti-inflammatory properties of isoxazolo[5,4-e]-1,2,4-triazepine (RM33) in vivo. The aim of this investigation was to describe synthesis, determine physicochemical characteristics, evaluate biological activities in murine and human in vitro models, as well as to propose mechanism of action of the compound. The compound was devoid of cell toxicity up to 100 μg/mL against a reference A549 cell line.
View Article and Find Full Text PDFVibrational Spectroscopy of Peritoneal Dialysis Effluent for Rapid Assessment of Patient Characteristics.
Biomolecules
June 2020
Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Peritoneal dialysis (PD) offers specific advantages over hemodialysis, enabling increased autonomy of patients with end-stage renal disease, but PD-related complications need to be detected in a timely manner. Fourier transform infrared (FTIR) spectroscopy could provide rapid and essential insights into the patients' risk profiles via molecular fingerprinting of PD effluent, an abundant waste material that is rich in biological information. In this study, we measured FTIR spectroscopic profiles in PD effluent from patients taking part in a randomized controlled trial of alanyl-glutamine addition to the PD-fluid.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!