The report covers the first case of insular thyroid cancer recorded in Croatian medical literature. A 71-year old female patient presented to our hospital with symptoms of inspiratory stridor. Clinical examination disclosed an expansive tumor mass. US guided FNA indicated anaplastic cancer and total thyroidectomy was accordingly indicated. Pathohistological analysis of H/E biopsies disclosed a tumor mass with a characteristic insular growth pattern of monomorphic tumor cells. Immunohistochemical analysis confirmed diagnosis by a diffuse positive reaction to thyreoglobulin, focally to TTF-1, and scant to cytokeratin, while calcitonin, FVIII, CD34 and LCA were clearly negative. P53 and bcl-2 were expressed in 35.9% and 85% of tumor cells, respectively. The proliferation index for Ki-67 was 4.19. According to our survey we suggest a panel of immunohistochemistry for diagnosing insular cancer. Even if partly present, insular cancer should be mentioned in the pathohistological description because of its prognostic meaning.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Pembrolizumab-induced autoimmune encephalitis in a woman with lentiginous melanoma.
Emergencias
June 2024
Servicio de Urgencias, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, España.
Serum cholesterol levels are inversely associated with the risk of malignancy in subjects with Bethesda category IV thyroid nodules.
Endocrinol Diabetes Nutr (Engl Ed)
July 2024
Section of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain; Research Institute in Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Spain. Electronic address:
Article Synopsis
- Some epidemiological data indicate a potential link between cholesterol levels and thyroid cancer risk, prompting this study to assess lipid profiles in patients with Bethesda category IV thyroid nodules.
- The study involved 204 patients who underwent thyroid surgery and had prior lipid profile testing, comparing those diagnosed with cancer against those with benign conditions.
- Results showed that patients with thyroid cancer had significantly lower total cholesterol, LDL, and non-HDL cholesterol levels, with LDL being the only lipid measure independently associated with malignancy; follicular carcinoma patients had the lowest cholesterol levels.
An Unusual Mixed Thyroid Carcinoma: A Surgical and Pathological Rarity.
Cureus
April 2024
Pathology, Sree Balaji Medical College and Hospital, Chennai, IND.
The incidence of mixed thyroid carcinoma of poorly differentiated thyroid carcinoma (PDTC) and papillary carcinoma thyroid is very unusual. PDTC exhibits a high degree of dedifferentiation and histopathological confirmation is done based on Turin's criteria. This type of carcinoma has a poor prognosis and the survival rates at five and ten years post-diagnosis are significantly lower compared to well-differentiated thyroid carcinomas.
View Article and Find Full Text PDFPoorly differentiated thyroid carcinoma arising from substernal goiter: a case report.
Ann Med Surg (Lond)
May 2024
Cancer Research Center, Tishreen University, Latakia.
Introduction And Importance: Poorly differentiated thyroid carcinomas represent a rare heterogeneous group of malignant tumors that constitute ~2-4% of all thyroid neoplasms. Substernal goiter (SG) is defined as an enlargement of the thyroid gland that is located below the thoracic inlet. Malignant neoplasms arising from a SG were reported in only 2-3% of cases.
View Article and Find Full Text PDFAnti-TIGIT antibody improves PD-L1 blockade through myeloid and T cells.
Nature
March 2024
Genentech Inc., South San Francisco, CA, USA.
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone. However, there remains little consensus on the mechanism(s) of response with this combination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!