Procoralan (Ivabradine) is a novel, specific If--current inhibitor, inducing reduction in heart-rate through a direct effect on sinoatrial automaticity at rest and during exercise. Thereby the drug may prevent myocardial ischaemia. So far the indications for using Procoralan are the following: symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm, in whom betablockers are contraindicated or not tolerated.
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Appl Biochem Biotechnol
January 2025
Graduate School of Pharmaceutical Sciences, Osaka University, Suita Yamadaoka 1-6, Suita, Osaka, 565-0871, Japan.
γ-Glutamylcysteine (γ-EC) can increase intracellular glutathione (GSH) levels, which may prevent and alleviate age-related disorders and chronic diseases caused by oxidative damage. However, the commercial availability of γ-EC remains limited owing to its complex chemical synthesis from glutamate and cysteine. In this study, we have developed the method of the effective conversion of GSH to γ-EC to achieve the optimal reaction conditions for repeated batch production and potential application in industrial γ-EC production using the phytochelatin synthase-like enzyme NsPCS.
View Article and Find Full Text PDFJ Glaucoma
January 2025
Department of Ophthalmology and Visual Sciences, University of British Colombia, Vancouver, BC.
Precis: Goniotomy is effective in managing intraocular pressure in childhood glaucoma secondary to uveitis with cumulative probability of success 0.94 after 1 year and 0.77 after 5 years.
View Article and Find Full Text PDFBMC Nephrol
January 2025
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Background: IgA nephropathy (IgAN) exhibits an unpredictable trajectory, creating difficulties in prognostication, monitoring, treatment, and research planning. This study provides a comprehensive depiction of the progression of kidney function throughout the disease course, from diagnosis to a span of 36 years post-diagnosis.
Methods: We utilized a cohort of 400 Norwegian IgAN patients, from diagnosis to the occurrence of death, initiation of kidney replacement therapy (KRT), or the latest follow-up.
Clin Res Hepatol Gastroenterol
January 2025
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address:
Background: Covalently closed circular DNA (cccDNA) is a stable, episomal form of HBV DNA. cccDNA is a true marker for the intrahepatic events in controlled CHB infection. Quantifying cccDNA is critical for monitoring disease progression, and efficacy of anti-viral therapies.
View Article and Find Full Text PDFVasc Med
January 2025
Oncology Department, Hospital Arnau de Vilanova, Valencia, Spain.
Background: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.
Methods: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up.
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