In this study, polyacrylamide disc gel electrophoresis and densitometry analysis methods were used to analyze venom extracts of Vipera xanthina specimens of different lengths (35, 47 and 88 cm) collected from the same locality. The electropherograms of the venom protein samples showed age-dependent qualitative and quantitative variations.
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Paraspecific neutralization capacity of polyvalent snake antivenom against Montivipera wagneri venom.
Toxicon
October 2024
Microbiology and Reference Laboratory and Biological, Products Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address:
Purpose: This study aims to measure the paraspecific neutralization capacity of nationally produced HSGM polyvalent snake antivenom (HSGM-PSAV), produced using Macrovipera lebetina obtusa, Montivipera xanthina, and Vipera ammodytes montandoni venom, against the lethal effect of the venom of Montivipera wagneri, which is endemic to the Eastern Black Sea and Eastern Anatolia regions of Turkey.
Methods: The neutralization capacity of HSGM-PSAV against the lethal effect of M. wagneri venom was studied using the potency determination testing method specified in the Turkish and European Pharmacopoeia.
Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera , , , and across Türkiye.
J Proteome Res
August 2024
Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany.
Snake venom variations are a crucial factor to understand the consequences of snakebite envenoming worldwide, and therefore it is important to know about toxin composition alterations between taxa. Palearctic vipers of the genera , , and have high medical impacts across the Old World. One hotspot for their occurrence and diversity is Türkiye, located on the border between continents, but many of their venoms remain still understudied.
View Article and Find Full Text PDFAntivenom for European Vipera species envenoming.
Clin Toxicol (Phila)
July 2017
a Department of Pharmacology, Toxicology, and Therapeutics , University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh , UK.
Background: European viper bite is relatively uncommon but can cause serious envenoming, particularly swelling and hemorrhage spreading from limb to trunk that can cause long term disability. Systemic features are relatively mild compared to many other venomous species. Moderate-to-severe envenoming requires antivenom, which is given many hundreds of times each year across the continent.
View Article and Find Full Text PDFNeutralization of Vipera and Macrovipera venoms by two experimental polyvalent antisera: a study of paraspecificity.
Toxicon
June 2011
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico.
We conducted an extensive study of neutralization of lethality of 11 species and one subspecies of snakes of the genus Vipera, and of five species of Macrovipera, by two experimental equine antisera. One antiserum was a trivalent preparation raised against the venoms of Vipera aspis aspis, Vipera berus berus and Vipera ammodytes ammodytes; the other was a pentavalent preparation that also included venoms of Vipera (now Montivipera) xanthina and Macrovipera lebetina obtusa. We measured specific neutralization of lethality against all venoms included in the immunization schemes, and paraspecific neutralization against the venoms of Vipera ammodytes montandoni, Vipera (Montivipera) bornmuelleri, Vipera latastei, Vipera (Mo.
View Article and Find Full Text PDFAge-dependent variations in the venom proteins of Vipera xanthina (Gray, 1849) (Ophidia: Viperidae).
Turkiye Parazitol Derg
October 2007
Ege University Science Faculty Department of Zoology, Bornova, Izmir, Turkey.
In this study, polyacrylamide disc gel electrophoresis and densitometry analysis methods were used to analyze venom extracts of Vipera xanthina specimens of different lengths (35, 47 and 88 cm) collected from the same locality. The electropherograms of the venom protein samples showed age-dependent qualitative and quantitative variations.
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