AI Article Synopsis
- Memantine and celecoxib, when used together, effectively inhibit hematoma growth and reduce inflammation in cases of intracerebral hemorrhage (ICH).
- Rats treated with both drugs showed a significant reduction in brain swelling and better recovery compared to those treated with just one drug or with nothing.
- The study indicates that the combination therapy could be a more effective approach for neuroprotection and managing inflammation in ICH treatment.
Article Abstract
Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment.
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| http://dx.doi.org/10.1016/j.neulet.2006.10.050 | DOI Listing |
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