This study was conducted to evaluate the appropriateness of the out-of-hours computed tomography (CT) head scans (scans performed outside normal working hours) in a large district general hospital in the United Kingdom. CT scan request forms and CT reports of adult patients were reviewed who had their CT head scans done between 1700 and 0900 h the next day and all weekend and national holidays in the study period of 4 months. Information regarding change in the patient management resulting from CT scan was extracted from review of patients' case notes. An urgent CT head scan request was deemed appropriate if it led to an immediate change in a patient's management. Appropriateness of the requests according to the various guidelines was also evaluated. One hundred and twenty-one patients were included in the study. Majority (70%) of the scans were requested by the emergency department. Eighty-one (66%) scans were both requested and performed between 1700 and 2200 h. Immediate change in management of 80% patients occurred. In 20 (17%), the change in management occurred only after 0900 h the next day and in 4 (3%), management did not change at all. Common scenarios involving change in patient's management included intracranial bleed requiring urgent neurosurgical intervention and hemorrhagic stroke being ruled out. Out-of-hours CT head scans also facilitated early discharge of the patients with head injuries and headache from the hospital. This retrospective study has found that a high proportion of out-of-hours CT head scans were appropriate and led to change in the patient's immediate medical care.
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http://dx.doi.org/10.1007/s10140-006-0531-7 | DOI Listing |
Clin Transl Radiat Oncol
March 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Aim: This study leveraged standard-of-care CT scans of patients receiving unilateral radiotherapy (RT) for early tonsillar cancer to detect volumetric changes in the carotid arteries, and determine whether there is a dose-response relationship.
Methods: Disease-free cancer survivors (>3 months since therapy and age > 18 years) treated with intensity modulated RT for early (T1-2, N0-2b) tonsillar cancer with pre- and post-therapy contrast-enhanced CT scans available were included. Patients treated with definitive surgery, bilateral RT, or additional RT before the post-RT CT scan were excluded.
Neurophotonics
January 2025
California Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.
Significance: Cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics for regional cerebrovascular monitoring. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting.
Aim: We aim to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain.
Shoulder Elbow
January 2025
Department of Orthopaedic Surgery, Tauranga Hospital, Tauranga, New Zealand.
Background: The underlying shoulder pathology in radiographic superior escape of the humeral head and association between acromiohumeral interval (AHI) on radiographs and magnetic resonance imaging (MRI) are poorly understood.
Methods: A retrospective review of shoulder radiographs and MRI scans was undertaken. AHI was measured using both modalities.
Adv Healthc Mater
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, P. R. China.
Noise-induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage to sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery to the inner ear. This study applied a retro-auricular round window membrane (RWM) method to bypass the BLB, enabling the transport of macromolecular proteins into the inner ear.
View Article and Find Full Text PDFJ Alzheimers Dis
January 2025
Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Brisbane, QLD, Australia.
Background: The introduction of therapeutics for Alzheimer's disease has led to increased interest in precisely quantifying amyloid-β (Aβ) burden for diagnosis, treatment monitoring, and further clinical research. Recent positron emission tomography (PET) hardware innovations including digital detectors have led to superior resolution and sensitivity, improving quantitative accuracy. However, the effect of PET scanner on Centiloid remains relatively unexplored and is assumed to be minimized by harmonizing PET resolutions.
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