Ca2+ is an important positive ion in the living body. Recently, there have been quite a few reports about the function of Ca2+ in sperm. Calcium is considered as a regulator of sperm motility, a participant in sperm capacitation, and an essential second messenger for acrosome reaction. This paper reviews the relationship of Ca2+ with sperm function.
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Article Synopsis
- The CatSper channel is crucial for sperm fertility as it regulates calcium signaling necessary for sperm movement.
- CATSPERε, a specific subunit of this channel, is vital for assembling the entire CatSper complex and enabling sperm hyperactivation.
- Mice lacking CATSPERε are sterile due to defective sperm, highlighting the importance of this subunit in fertility and potential therapeutic targets.
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