Supercompensated glycogen loads persist 5 days in resting trained cyclists.

Eur J Appl Physiol

East Tennessee State University, Physical Therapy Program, PO Box 70624, Johnson City, TN 37614, USA.

Published: February 2007

Research data indicates a persistence of elevated muscle glycogen concentration 3 days post-supercompensation in resting athletes. This study expands our earlier findings by determining whether muscle glycogen remains elevated 3, 5, or 7 days post-supercompensation. Seventeen trained male cyclists underwent one bout of exhaustive exercise to deplete muscle glycogen. This was followed by a 3-day consumption of a high carbohydrate/low protein/low fat diet (85:08:07%). Three post-loading phases followed with subjects randomly assigned to either a 3-day, 5-day, or 7-day post-loading maintenance diet of 60% carbohydrate and limited physical activity. Biopsies (50-150 mg) of the vastus lateralis were obtained pre-load (BASELINE), at peak-load (PEAK), and either at 3-day, 5-day, or 7-day post-load (POST). On average, PEAK to POST muscle glycogen concentrations decreased 34, 20 and 46% respectively for the 3-, 5-, and 7-day POST groups. Only the 7-day post-load group's PEAK to POST mean muscle glycogen concentration decreased significantly. In addition, multi-regression analysis indicated that the PEAK glycogen level was the main determinant of the number of days that glycogen levels remained significantly greater than BASELINE. Thus, trained athletes' supercompensated glycogen levels can remain higher than normal for up to 5 days post-loading. The amount of carbohydrate consumed, the level of physical activity, and the magnitude of the glycogen supercompensation determine the interval for which the glycogen levels are elevated.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00421-006-0340-4DOI Listing

Publication Analysis

Top Keywords

muscle glycogen
20
glycogen levels
12
glycogen
10
supercompensated glycogen
8
glycogen concentration
8
days post-supercompensation
8
3-day 5-day
8
5-day 7-day
8
physical activity
8
7-day post-load
8

Similar Publications

Intramuscular inhibition of glycogen phosphorylase improves motor function in spinal cord injury.

Biochem Biophys Res Commun

January 2025

Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Motor dysfunction in various diseases and aging is often accompanied by skeletal muscle atrophy and reduced axonal projections from motor neurons to the skeletal muscles. While several studies have investigated the correlations and molecular mechanisms between muscle atrophy and motor neuron denervation to explain the pathology of motor diseases, it remains unclear whether skeletal muscle atrophy directly causes axonal denervation of motor neurons. Here, we used a casts-attached mouse model which represents muscle atrophy and motor dysfunction in the hindlimbs to explore how skeletal muscle atrophy affects motor neuronal axon projections.

View Article and Find Full Text PDF

Genetics of Muscle Disease.

Vet Clin North Am Equine Pract

January 2025

Department of Veterinary Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Room 4206 Vet Med 3A One Shields Avenue, Davis, CA 95616, USA. Electronic address:

In the field of equine muscle disorders, many conditions have a genetic basis. Therefore, genetic testing is an important part of the diagnostic evaluation. Validated genetic tests are currently available for 5 equine muscle disorders: hyperkalemic periodic paralysis, malignant hyperthermia, glycogen branching enzyme disease, type 1 polysaccharide storage myopathy, and myosin heavy chain myopathy.

View Article and Find Full Text PDF

Myofibrillar Myopathy.

Vet Clin North Am Equine Pract

January 2025

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:

Myofibrillar myopathy (MFM) is characterized by segmental disarray of myofibrils and ectopic accumulation of a protein called desmin. Previously thought to be a glycogen storage disease, MFM is now recognized as a stand-alone myopathy. Endurance Arabians with MFM usually present with exertional rhabdomyolysis (MFM-ER) at the end of races, elevated serum muscle enzymes, and myoglobinuria.

View Article and Find Full Text PDF

Management of presymptomatic juvenile patients with late-onset Pompe disease (LOPD).

Neuromuscul Disord

January 2025

ERN-NMD Center for Neuromuscular Disorders of Messina - Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address:

Late-onset Pompe disease (LOPD) includes patients from 1 year of age to adulthood. The vast heterogeneity in clinical manifestations and disease progression is not fully explained; however, a short disease duration and a young age seem to be good predictors of a better response to treatment. For this purpose, we investigated and followed up a cohort of 13 juvenile patients with LOPD from the clinical and therapeutic point of view, mainly pointing out the transition from presymptomatic to symptomatic status.

View Article and Find Full Text PDF

High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue.

Life Metab

October 2024

Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

Obesity is considered an epidemic often accompanied by insulin resistance (IR). Heat treatment (HT) has been shown to prevent high-fat diet-induced IR in skeletal muscle, but the underlying mechanisms are poorly understood. In this study, we discovered that high temperature alleviated the hallmarks of obesity by promoting glycogen synthesis and lowering blood glucose levels in skeletal muscle tissue (SMT).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!