The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja066199i | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multimodal treatment improves survival in patients with lung metastases from colorectal cancer: A network meta-analysis.
Colorectal Dis
January 2025
Digestive Surgery and Liver Transplantation Unit, Archet 2 Hospital, Centre Hospitalier Universitaire de Nice, Nice, France.
Aim: The lungs represent the second most common site of colorectal cancer metastases. Although surgery is commonly considered the best treatment, many other invasive and noninvasive procedures and treatments have been adopted to improve patient survival and there is no clear evidence in the literature of which is the more effective. The aim of this work was to identify which treatment confers the best gain in overall survival for patients with pulmonary metastases from colorectal cancer.
View Article and Find Full Text PDFTracking and Navigation Technologies for Image-Guided Trans-Arterial Interventions.
Tech Vasc Interv Radiol
December 2024
Department of Radiology, Mayo Clinic, Phoenix, AZ. Electronic address:
Trans-arterial interventions are an increasingly utilized approach for diagnosing and treating a wide range of pathologies, providing superior patient outcomes compared to traditional open surgical methods. Recent advancements in tracking and navigation technologies have significantly refined these interventions, enhancing procedural precision and success. Advanced imaging modalities, such as fluoroscopy, cone beam computed tomography (CBCT), and intravascular ultrasound (IVUS), are frequently used strategies offering critical real-time guidance.
View Article and Find Full Text PDFFusion Technologies for Image-Guided Robotic Interventions.
Tech Vasc Interv Radiol
December 2024
Center for Interventional Oncology, Radiology, and Imaging Sciences, NIH Clinical Center, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD.
An image guided robot only becomes fully useful with integrated software leveraging image fusion. Image fusion is the process of registering and superimposing imaging data in the same coordinate space and can be helpful to image-guided robotic interventions. Effective percutaneous robotic procedures can utilize real-time image guidance and navigation which are powered by fusion technologies.
View Article and Find Full Text PDFSarkoLife: quality of life in patients undergoing multimodal soft tissue sarcoma treatment.
World J Surg Oncol
January 2025
Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, Tuebingen, 72076, Germany.
Objective: To assess the tolerability of multimodal therapy in soft tissue sarcoma patients, particularly with regard to their quality of life and level of distress.
Materials And Methods: A retrospective cohort study enrolled individuals receiving sarcoma therapy at the sarcoma center of the University of Tuebingen between 2017 and 2022. Participants completed an online survey that included the EORTC's questionnaire (QLQ-C30), coupled with the distress thermometer and demographic inquiries.
Complex Large-Deformation Multimodality Image Registration Network for Image-Guided Radiotherapy of Cervical Cancer.
Bioengineering (Basel)
December 2024
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
In recent years, image-guided brachytherapy for cervical cancer has become an important treatment method for patients with locally advanced cervical cancer, and multi-modality image registration technology is a key step in this system. However, due to the patient's own movement and other factors, the deformation between the different modalities of images is discontinuous, which brings great difficulties to the registration of pelvic computed tomography (CT/) and magnetic resonance (MR) images. In this paper, we propose a multimodality image registration network based on multistage transformation enhancement features (MTEF) to maintain the continuity of the deformation field.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!