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Nuclear Condensates of WW Domain-Containing Adaptor With Coiled-Coil Regulate Mitophagy via Alternative Splicing.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled-coil (WAC) is localized to nuclear speckles via its WW domain and plays a pivotal role in regulating alternative splicing through the formation of biomolecular condensates via its C-terminal coiled-coil (CC) domain. WAC acts as a scaffold protein and facilitates the integration of RNA-binding motif 12 (RBM12) into nuclear speckles, where RBM12 potentially interacts with the spliceosomal U5 small nuclear ribonucleoprotein (snRNP).
View Article and Find Full Text PDFInvestigation into Alzheimer's-related amyloid-β conformational transformations and stability influenced by green iron oxide nanoparticles (GIONP).
Int J Biol Macromol
January 2025
Biophysics Department, Faculty of Science, Cairo University, 12613 Giza, Egypt. Electronic address:
Alzheimer's disease (AD) is popularly believed to be triggered by the aggregation of amyloid beta 1-42 (Aβ - 42) peptides, eventually leading to neurodegeneration. Our study delves into the influential role played by Green Iron Oxide Nanoparticles (GIONP). GIONP are typically synthesized using a green chemistry approach, imposing curcumin as a biocompatible reducing and capping agent, leveraging its inherent antioxidant, anti-inflammatory, and neuroprotective attributes.
View Article and Find Full Text PDFUsing Transcriptomic Signatures to Elucidate Individual and Mixture Effects of Inorganic Arsenic and Manganese in Human Placental Trophoblast HTR-8/SVneo Cells.
Toxicol Sci
January 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Prenatal exposure to the toxic metal inorganic arsenic (iAs) is associated with adverse pregnancy and fetal growth outcomes. These adverse outcomes are tied to physiological disruptions in the placenta. While iAs co-occurs in the environment with other metals such as manganese (Mn), there is a gap in the knowledge of the effects of metal-mixtures on the placenta.
View Article and Find Full Text PDFLack of TRIC-B dysregulates cytoskeleton assembly, trapping β-catenin at osteoblast adhesion sites.
FEBS J
January 2025
Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Italy.
The trimeric intracellular cation channel B (TRIC-B), encoded by TMEM38B, is a potassium (K) channel present in the endoplasmic reticulum membrane, where it counterbalances calcium (Ca) exit. Lack of TRIC-B activity causes a recessive form of the skeletal disease osteogenesis imperfecta (OI), namely OI type XIV, characterized by impaired intracellular Ca flux and defects in osteoblast (OB) differentiation and activity. Taking advantage of the OB-specific Tmem38b knockout mouse (Runx2Cre;Tmem38b; cKO), we investigated how the ion imbalance affects the osteogenetic process.
View Article and Find Full Text PDFCorrection: Pathologically altered articular cartilage attracts intense chondrocyte invasion into the extracellular matrix: in vitro pilot study.
Knee Surg Relat Res
January 2025
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036, Obninsk, Russia.
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