AI Article Synopsis
- The study examines histological changes in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry.
- It found a significant loss of large VP neurons in the hypothalamus while smaller neurons remained intact.
- The neurohypophysis (part of the pituitary gland) showed severe atrophy, indicating that HDI may be due to selective degeneration of neurons that primarily project to this area.
Article Abstract
We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing of the parvocellular component may reflect the projection of these neurons to non-pituitary targets.
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| http://dx.doi.org/10.1007/BF00305879 | DOI Listing |
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