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Article Synopsis
  • * Although some people may not show symptoms, adrenal hemorrhage is a rare but serious complication that could be missed until autopsy.
  • * The report discusses a case of a woman in her 30s whose undiagnosed pheochromocytoma led to hemorrhagic conversion, highlighting the importance of quick diagnosis and treatment.
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Incidence of thyroid dysfunctions including hypo- or hyperthyroidism is significantly increased. Hyperthyroidism is common in males, and hypothyroidism is often seen in females. Here, we report two female patients suffering from hyperthyroidism, but their signs and symptoms are totally opposite to each other.

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Article Synopsis
  • - Takotsubo cardiomyopathy (TCM) is a heart condition triggered by extreme physical or emotional stress, linked to factors like thyroid storm and cocaine use.
  • - A case study describes a 26-year-old male with Graves' disease and cocaine issues, who experienced TCM and cardiogenic shock due to a thyroid storm.
  • - The patient underwent intensive treatment, including extracorporeal membrane oxygenation, and successfully recovered his heart function after receiving antithyroid medications and steroids.
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The Pheochromocytoma/Paraganglioma syndrome: an overview on mechanisms, diagnosis and management.

Int Braz J Urol

May 2023

Unidade de Adrenal e Hipertensão, Divisão de Endocrinologia e Metabolismo, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brasil.

Pheochromocytomas/paragangliomas (PPGL) are rare, metastatic, and potentially fatal neuroendocrine tumors, often neglected because they present symptoms similar to other prevailing clinical conditions such panic syndrome, thyrotoxicosis, anxiety, hypoglycemia, etc., delaying diagnosis and treatment. The rate of diagnosis of PPGL has been increasing with the improvement in the measurement of catecholamine metabolites and the expanding availability of imaging procedures.

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Atrial fibrillation is a common manifestation seen in patients with hyperthyroidism and thyroid storm. The presence of excess thyroid hormone (TH) alters adrenergic receptors in the heart and blood vessels, thereby causing an increase in sympathetic function and atrial fibrillation as a sequela of this excess circulating hormone. Excess thyroid hormone (T3) shortens the action potential of cardiomyocytes in the pulmonary vein, which facilitates the generation of reentrant circuits causing atrial fibrillation.

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