Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913233 | PMC |
| http://dx.doi.org/10.1128/AAC.00580-06 | DOI Listing |
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