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http://dx.doi.org/10.1182/blood-2006-04-014621 | DOI Listing |
Turk J Biol
July 2022
UKM Medical Molecular Biology Institute (UMBI), National University Malaysia, Cheras, Malaysia.
Colorectal cancer (CRC) is a malignant tumor arising from a human inner colon lining that may spread to other organs such as the liver and lungs. Per ARNT Sim domain containing 1 (PASD1) is a cancer-testis antigen expressed in cancers including CRC but not in normal tissues except for normal testes. This study aims to study PASD1 protein as a potential target for CRC immunotherapy.
View Article and Find Full Text PDFTP53 mutations are the most frequent mutations in hepatocellular carcinoma (HCC) and affect the occurrence and development of this cancer type. Therefore, it is essential to clarify the function and mechanism of TP53 mutations in HCC. We performed a sequence of bioinformatic analyses to elucidate the characteristics of TP53 mutations in HCC.
View Article and Find Full Text PDFPathol Res Pract
January 2021
N.N. Petrov National Medical Research Center of Oncology, 197758, Russian Federation St. Petersburg, Pesochny, Leningradskaya Street 68, Russia. Electronic address:
Med Sci Monit
September 2019
Department of Neurosurgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China (mainland).
BACKGROUND PAS domain containing repressor 1 (PASD1), the cancer-testis antigen (CTA), has been reported to be aberrantly expressed in various cancer tissues and cancer cell lines; however, normal PASD1 expression can be detected in normal tissue, excluding testicular tissue. Moreover, PASD1 is reported to be abnormally expressed in various malignant tumors. However, it remains unclear whether PASD1 participates in tumorigenesis of glioma.
View Article and Find Full Text PDFImmunotherapy
October 2019
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Colorectal cancer is the third commonest malignancy in Asia including Malaysia. The immunogenic cancer-testis antigens, which are expressed in a variety of cancers but with limited expression in normal tissues except the testis, represent an attractive approach to improve treatment options for colorectal cancer. We aimed to validate four PASD1 peptides as the immunotherapeutic targets in colorectal cancer.
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