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First-Line Mobocertinib Versus Platinum-Based Chemotherapy in Patients With Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer in the Phase III EXCLAIM-2 Trial.
J Clin Oncol
January 2025
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of China, Shatin, Hong Kong Special Administrative Region, China.
Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.
View Article and Find Full Text PDFHigher stability of nanophase GdO-CeO upon 400 keV Kr ion irradiation over bulk: role of defect annealing across grain boundaries.
Phys Chem Chem Phys
January 2025
Department of Physics, Indian Institute of Technology (IIT) Delhi, New Delhi 110016, India.
The concept of inert matrix fuel (IMF) has been proposed to utilize the energetic value of Pu and transmute minor actinides in nuclear reactors. In order to offset the initial reactivity of nuclear fuel, gadolinium (Gd) is employed as a burnable poison, owing to its high neutron absorption cross-section. To gain insights into the radiation stability and influence of grain boundaries on irradiation behaviour, 5 mol% Gd-doped ceria samples, sintered at varying temperatures, were subjected to irradiation using 400 Kr ions.
View Article and Find Full Text PDFIntegrating attention mechanism and boundary detection for building segmentation from remote sensing images.
Front Neurorobot
January 2025
College of Artificial Intelligence, Taiyuan University of Technology, Jinzhong, Shanxi, China.
Accurate building segmentation has become critical in various fields such as urban management, urban planning, mapping, and navigation. With the increasing diversity in the number, size, and shape of buildings, convolutional neural networks have been used to segment and extract buildings from such images, resulting in increased efficiency and utilization of image features. We propose a building semantic segmentation method to improve the traditional Unet convolutional neural network by integrating attention mechanism and boundary detection.
View Article and Find Full Text PDFTowards contrast-agnostic soft segmentation of the spinal cord.
Med Image Anal
January 2025
NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Québec, Canada; Mila - Québec Artificial Intelligence Institute, Montréal, Québec, Canada; Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Québec, Canada; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada. Electronic address:
Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi and automatic methods exist, one key limitation remains: the segmentation depends on the MRI contrast, resulting in different CSA across contrasts. This is partly due to the varying appearance of the boundary between the spinal cord and the cerebrospinal fluid that depends on the sequence and acquisition parameters.
View Article and Find Full Text PDFFactors influencing experiences of non-consensual sex: results from a mixed data cross-sectional online survey of Australian university students.
Sex Health
January 2025
School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, Qld, Australia.
Background The high prevalence of non-consensual sex, including physical force, verbal threats, intimidation, and/or verbal coercion and rape among university students, has prompted urgent calls for action from governments, statutory, and university bodies. This research aims to identify key factors students see as contributing to non-consensual sex with a view to developing effective strategies to address these issues. Methods An online cross-sectional survey was administered to 4291 university students attending universities in south-east Queensland, Australia.
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