Diabetes is one of the most challenging problems in the 21st century, whereby research showed that reducing the concentration of blood glucose is thought to prevent or reduce the long-term complications. To do so, a multidisciplinary approach is favourable. In Belgium, a revalidation programme for the diabetic patients concerning self-regulation was introduced followed by the introduction of the Diabetes Pass in March 2003 whereby some goals were stipulated. In IBBT-COPLINTHO, a still ongoing project, an eHomeCare platform is implemented whereby the patient is the central actor. The analysis of the current paper-based Diabetes Pass revealed that the data can be easily extracted from the EHR. An electronic alternative for the Diabetes pass is proposed whereby the added values for the patient are underlined. Before implementing the electronic alternative, some research should still be done, but it is thought that all the actors involved--including the patient, could easily benefit from the electronic alternative.
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Sci Rep
January 2025
Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Heliotropium indicum is well-known for its diverse medicinal properties, traditionally utilized to treat ailments such as diabetes, obesity, bacterial infections, inflammation, and diarrhea. This study aims to explore the anti-inflammatory effects of the extract using in vitro methods and to assess its drug-likeness potential using docking, PASS and ADME. Fractionations of crude methanol extract (CME) were undertaken in n-hexane (NHF), chloroform (CHF), and ethyl acetate (EAF).
View Article and Find Full Text PDFClinics (Sao Paulo)
January 2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brasil.
Background: Individuals with severe obesity and type 2 diabetes mellitus have reduced secretion of incretins by L cells. Studies suggest an increase in L cell activity according to the length of the Biliopancreatic Loop (BPL).
Objective: Compare the effect of biliopancreatic loop extension on the number and expression of L cells in patients undergoing RYGB METHODS: Subjects (n = 13) undergoing RYGB with a BPL of 100 cm (G1) or 200 cm (G2).
Urolithiasis
January 2025
Department of Urology, Gaziosmanpasa Training and Research Hospital, Karayolları Mahallesi, Osmanbey Caddesi, 621 Sokak, Gaziosmanpaşa, Istanbul, Turkey.
Percutaneous nephrolithotomy (PCNL) is a widely preferred method for treating complex kidney stones, particularly in patients with larger or more complicated stones. Despite its advantages, such as minimal invasiveness and a shorter recovery time, postoperative complications can occur, thereby necessitating effective risk assessment tools to identify at-risk patients. This study evaluated the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system's utility in predicting postoperative complications following standard PCNL.
View Article and Find Full Text PDFGenet Epidemiol
January 2025
JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an outcome of interest, for example, disease risk in a GWAS, at high levels of statistical significance, but with very small effects.
View Article and Find Full Text PDFOphthalmol Sci
October 2024
Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey.
Objective: To investigate retinal vascular permeability mapping as a potential biomarker for diabetic retinopathy in subjects with diabetes with no signs of retinopathy and with mild nonproliferative retinopathy.
Design: This is a case-control study.
Subjects: Participants included 7 healthy controls, 22 subjects with diabetes mellitus and no clinical signs of retinopathy (DMnoDR), and 7 subjects with mild nonproliferative diabetic retinopathy (NPDR).
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