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Dynamic reactive synthesis of bio-based compatibilizer via diepoxide monomers grafting polylactic acid and reactive compatibilization of incompatible polylactic acid/bamboo powder composites.
Int J Biol Macromol
March 2025
School of Chemistry and Chemical Engineering Hainan University, Haikou 570228, Hainan Province, China; Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province, Laboratory of Polymers and Composites, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, Zhejiang Province, China. Electronic address:
The synthesis of monomers with two epoxy structures (EIA) was successfully achieved by adopting holo-biobased feedstocks and in situ solvolysis reaction. The molecular structure of EIA was subjected to characterization through the use of infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance hydrogen spectroscopy (H NMR). The EIA was employed as the epoxy monomers for the synthesis of the grafted compatibilizer, resulting in the successful preparation of a fully bio-based and high epoxy value grafted compatibilizer (PLA-g-EIA (PLE)).
View Article and Find Full Text PDFDiscovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation.
Int J Biol Macromol
March 2025
State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China. Electronic address:
Caseinolytic protease P (ClpP) protein is essential for prokaryotic and eukaryotic protein homeostasis, and has emerged as a promising bactericidal target for controlling bacterial infection and evading the emergent of drug-resistance risk. As the unique bactericidal mechanism, ClpP loses its substrate specificity and undergoes uncontrolled protein hydrolysis in the presence of an activator, leading to causing bacterial death. To further expand the chemotype of ClpP activator, a series of ONC212 derivatives were synthesized using a ring expansion strategy.
View Article and Find Full Text PDFResearch note: In vitro anticoccidial activity of protein and lipid extracts from the black soldier fly larvae (Hermetia illucens).
Poult Sci
March 2025
INRAE, UMR ISP, Université de Tours, Nouzilly 37380, France. Electronic address:
Avian coccidiosis, caused by Eimeria spp., is the main parasitic disease in the poultry industry, responsible for high economic costs worldwide. Faced with anticoccidial resistance and societal pressure to reduce inputs in livestock sector, insects could provide a relevant alternative to anticoccidial molecules.
View Article and Find Full Text PDFN-of-1 trials are currently receiving broader attention in healthcare research when assessing the effectiveness of interventions. In contrast to the most commonly applied two-arm randomized controlled trial (RCT), in an N-of-1 design, the individual acts as their own control condition in the sense of a multiple crossover trial. N-of-1 trials can lead to a higher quality of patient by examining the effectiveness of an intervention at an individual level.
View Article and Find Full Text PDFSynthesis, Antifungal Activity and In Silico Study of Novel Quinoline Thioether Derivatives Inspired by Natural Quinoline.
Chem Biodivers
March 2025
Zhejiang University of Technology, College of Chemical Engineering, chaowang road 18, 310014, Hangzhou, CHINA.
Inspired by natural quinoline, a series of novel quinoline derivatives containing thioether groups were designed and synthesized. All target compounds were characterized using 1H NMR, 13C NMR, and HRMS. Their antifungal activities were evaluated in vitro against ten phytopathogenic fungi.
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