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Improving care in elderly neurosurgery initiative guideline on management of chronic subdural haematoma in older people-relevance for the geriatrician.
Age Ageing
January 2025
North Bristol NHS Trust - Geriatric Medicine, Southmead Hospital, Southmead Road, Bristol BS10 5NB, UK.
Chronic subdural haematoma (cSDH) is a common subtype of traumatic brain injury, typically affecting older people living with frailty and multimorbidity. Until now, no published guideline has existed internationally to guide management, perhaps explaining why the care of the older cSDH patient varies between neurosurgical centres. The Improving Care in Elderly Neurosurgery Initiative guideline is the first guideline dedicated to the care of patients with cSDH across the entire patient pathway, from initial presentation through to rehabilitation and discharge after surgery.
View Article and Find Full Text PDFThe Accreditation Council for Occupational Therapy Education (ACOTE®) Standards and Interpretive Guide provides the required elements for educational programs and establishes critical competencies necessary to prepare students to become entry-level occupational therapists (OTs) or occupational therapy assistants (OTAs). The Standards review process is completed every 5 years to ensure that the entry-level educational standards reflect current occupational therapy practice. ACOTE uses a comprehensive review process to ensure participation by all stakeholders and communities of interest.
View Article and Find Full Text PDFA comprehensive benchmarking for evaluating TCR embeddings in modeling TCR-epitope interactions.
Brief Bioinform
November 2024
Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, 999077, China.
The complexity of T cell receptor (TCR) sequences, particularly within the complementarity-determining region 3 (CDR3), requires efficient embedding methods for applying machine learning to immunology. While various TCR CDR3 embedding strategies have been proposed, the absence of their systematic evaluations created perplexity in the community. Here, we extracted CDR3 embedding models from 19 existing methods and benchmarked these models with four curated datasets by accessing their impact on the performance of TCR downstream tasks, including TCR-epitope binding affinity prediction, epitope-specific TCR identification, TCR clustering, and visualization analysis.
View Article and Find Full Text PDFRevised Process for ACNS Guidelines Development.
J Clin Neurophysiol
February 2025
Division of Child Neurology, Department of Neurology, Stanford University, Palo Alto, California, U.S.A.
The development of clinical practice guidelines is an evolving field. In response to the need for consistent, evidence-based medical practice, the American Clinical Neurophysiology Society identified the need to update the Society's guideline development process. The American Clinical Neurophysiology Society Guidelines Committee created an action plan with the goal of improving transparency and rigor for future guidelines and bringing existing guidelines to current standards.
View Article and Find Full Text PDF[A comparative study of autonomous communities' legislation on accreditation of Research Ethics Committees as part of the principle of good governance].
Rev Esp Salud Publica
January 2025
Grupo de Investigación Discapacidad, Enfermedad Crónica y Accesibilidad a los Derechos; Universidad de Alcalá. Alcalá de Henares (Madrid). España.
Objective: Following a consultation received at the Legal Clinic of the University of Alcalá, it was necessary to determine whether or not a Research Ethics Committee was accredited. This led us to consider the need to determine whether the autonomous communities had reformed their legislation to establish the accreditation procedure for Research Ethics Committees, therefore adapting their legislation to Act 14/2007.
Methods: An analysis of the european, national and regional legislation regulating biomedical research in Spain was carried out to determine what the accreditation procedure for Research Ethics Committees was like in each autonomous community and whether it conformed to the provisions of Act 14/2007.
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