Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD).
Design: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks.
Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming.
Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS.
Results: Stimulation to the left and right DLPFC improved accuracy in action naming.
Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archneur.63.11.1602 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcranial magnetic stimulation combined with intracranial local field potential recordings in humans (TMS-iEEG) represents a new method for investigating electrophysiologic effects of TMS with spatiotemporal precision. We applied TMS-iEEG to the dorsolateral prefrontal cortex (dlPFC) in two subjects and demonstrate evoked activity in the subgenual anterior cingulate cortex (sgACC). This study provides direct electrophysiologic evidence that dlPFC TMS, as targeted for depression treatment, can modulate brain activity in the sgACC.
View Article and Find Full Text PDFTranscranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is an established intervention for treatment-resistant depression (TRD), yet the underlying therapeutic mechanisms remain not fully understood. This study employs an integrative approach that combines TMS with concurrent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), aimed at assessing the acute/immediate effects of TMS on brain network dynamics and their correlation with clinical outcomes. Our study demonstrates that TMS acutely modulates connectivity within vital brain circuits, particularly the cognitive control and default mode networks.
View Article and Find Full Text PDFEffect of DLPFC rTMS on anhedonia and alpha asymmetry in depressed patients.
Sci Rep
January 2025
Women's Operational Military Exposure Network Center of Excellence (WOMEN COE), VA Palo Alto Health Care System, Palo Alto, USA.
Anhedonia, a core symptom of depression, has been defined as the loss of pleasure or lack of reactivity to pleasurable stimuli. Considering the relevance of alpha asymmetry to MDD and anhedonia, we explored the effect of dorsolateral prefrontal cortex (DLPFC) stimulation on frontal and posterior EEG alpha asymmetry (FAA and PAA, respectively), in this exploratory investigation. 61 participants randomly received sham (n = 11), bilateral (BS; n = 25), or unilateral stimulation (US; n = 25) of the DLPFC.
View Article and Find Full Text PDFUnveiling the efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: A comprehensive review of systematic analyses.
PLoS One
January 2025
Department of Neurology, Sichuan Taikang Hospital, Chengdu, Sichuan, China.
Article Synopsis
- The study reviewed systematic reviews (SRs) on repetitive transcranial magnetic stimulation (rTMS) for Parkinson’s disease (PD) to clarify the evidence quality.
- Only 12.5% of the 16 SRs were rated as high quality, with many suffering from low or very low quality ratings according to rigorous evaluation tools.
- While rTMS was found to potentially improve motor symptoms in PD, its efficacy for non-motor symptoms remains unclear, indicating a need for future studies to enhance methodological standards and treatment comparisons.
Cerebrotendinous xanthomatosis: A complex interplay between a clinically and genetically heterogeneous condition.
Eur J Neurol
January 2025
Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.
Background And Purpose: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease characterized by abnormal bile acid synthesis. It often presents with systemic and neurological manifestations; however, atypical presentations can lead to significant diagnostic challenges. This case report highlights the diagnostic complexities and management considerations in a patient with an uncommon presentation of CTX.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!