Assessment of dynamic image analysis as a surrogate dissolution test for a coated multiparticulate product.

Pharm Dev Technol

Formulation Development, Actavis, Elizabeth, NJ 07207, USA.

Published: February 2007

Dynamic image analysis (DIA) was used to measure particle diameter (D50) of in-process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 mum. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was related to D50. DIA was assessed as a surrogate dissolution test with considerable potential. Current limitations of the approach were presented.

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http://dx.doi.org/10.1080/10837450600770072DOI Listing

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