AI Article Synopsis
- Researchers isolated a new nucleoside, N6-succinyladenosine, from the urine of colon carcinoma patients and normal subjects, featuring an aspartic acid group attached to a purine ribonucleoside.
- The structure of this nucleoside was confirmed through various methods including spectral data, chemical breakdown, and synthesis.
- Unlike similar nucleosides formed during RNA breakdown, this one likely originates from adenylosuccinic acid, an important precursor in the production of adenosine-5'-monophosphate (AMP).
Article Abstract
From the urines of colon carcinoma patients and normal subjects we have isolated a nucleoside in which an amino group of aspartic acid is attached to the six position of purine ribonucleoside. The structure, N6-succinyladenosine, N-(9-B-D-ribofuranosylpurin-6-yl)aspartic acid was assigned on the basis of spectral data, chemical degradation, and by synthesis. The ultraviolet and mass spectra, chromatographic and electrophoretic mobilities, and the chemical properties of the naturally occurring nucleoside were identical to those of the synthetic N6-succinyladenosine. In contrast to the methylated and hypermodified nucleosides which are products of RNA catabolism, this urinary nucleoside appears to be derived from adenylosuccinic acid, a key intermediate required in the biosynthesis of ubiquitous, natural purine nucleotide adenosine-5'-monophosphate (AMP).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC342476 | PMC |
| http://dx.doi.org/10.1093/nar/4.3.739 | DOI Listing |
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