There is an increasing number of antidepressants as well as not-phramacological therapies for treatment of major depressive disorders. Despite of this fact, there are still some treatment-resistant patients, who do not respond neither on antidepressants nor on antipsychotics (Wender 1988). Repetitive transcranial magnetic stimulation (Peschina et al. 2001), electroconvulsive therapy (Konig et al. 1991) and vagus nerve stimulation are some effective treatment options for those patients. For seasonal depressions light therapy has been proven to be effective. Actually Methylphenidate is in use for hyperkinetic and narcoleptic patients (Steinhausen 1995), but seems also to be effective for major depressive disorders as an add-on therapy (Sachdev et al. 2000). Steinhausen (1995) report a response rate among hyperkinetic patients of 75% and a lower one among depressive patients. This case report describes an 15 yr old patient with attention deficit hyperactivity disorder, who was initially treated psychopharmacologically (electroconvulsive therapy, vagus nerve stimulation and repetitive transcranial magnetic stimulation were refused) without a significant improvement. After having explored the seasonal association of the symptomatology, additional light therapy brought a remarkable improvement.
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Unlabelled: Strain-level variation among host-associated bacteria often determines host range and the extent to which colonization is beneficial, benign, or pathogenic. is a beneficial symbiont of the light organs of fish and squid with known strain-specific differences that impact host specificity, colonization efficiency, and interbacterial competition. Here, we describe how the conserved global regulator, H-NS, has a strain-specific impact on a critical colonization behavior: biofilm formation.
View Article and Find Full Text PDFComorbidity and its association with age are of great interest in geroscience. However, there are few model organisms that are well-suited to study comorbidities that will have high relevance to humans. In this light, we turn our attention to the companion dog.
View Article and Find Full Text PDFJ Cent Nerv Syst Dis
January 2025
CRCSEP, Université Nice Cote d'Azur, Nice, France.
Multiple sclerosis (MS) falls within the spectrum of central nervous system (CNS) demyelinating diseases that may lead to permanent neurological disability. Fundamental to the diagnosis and clinical surveillance is magnetic resonance imaging (MRI) that allows for the identification of T2-hyperintensities associated with autoimmune injury that demonstrate distinct spatial distribution patterns. Here, we describe the clinical experience of a 31-year-old, right-handed, White man seen in consultation at The University of Texas Southwestern Medical Center in Dallas, Texas, following complaints of headaches that began after head trauma related to military service.
View Article and Find Full Text PDFOrg Lett
January 2025
Organic Chemistry Department, Faculty of Science, Autonomous University of Madrid, 28049 Madrid, Spain.
The functionalization of the C-N bond of amines is a straightforward strategy for the construction of complex scaffolds or for the late-stage functionalization of pharmaceuticals. Herein, we describe a photoredox-catalyzed strategy for the deaminative alkylation of primary amine-derived isonitriles that provides unnatural amino acid derivatives under mild conditions. The use of silacarboxylic acids as silyl radical precursors enables the generation of carbon-centered radicals that allow the construction of Csp-Csp bonds via a Giese-type addition, avoiding the undesired hydrodeamination product.
View Article and Find Full Text PDFHum Genomics
January 2025
Division of Genome Science, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Chungbuk, 28159, Republic of Korea.
Background: Congenital anomalies (CAs) encompass a wide spectrum of structural and functional abnormalities during fetal development, commonly presenting at birth. Identifying the cause of CA is essential for accurate diagnosis and treatment. Using a target-gene approach, genetic variants could be found in certain CA patients.
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