A 72-year-old man presented with a history of progressive abdominal pain associated with simultaneous headache, constitutional syndrome, and weight loss. A CT scan demonstrated sclerosing mesenteritis (SM). A surgical biopsy of mesenteric tissue excluded malignancies and a temporal artery biopsy showed giant-cell arteritis, establishing the diagnosis of SM associated with giant-cell temporal arteritis (GCA). Both entities responded well to steroid therapy and relapsed simultaneously after steroid withdrawal. This association may be fortuitous, but it can also represent a unique clinical setting. We suggest ruling out GCA every time a SM is encountered in the appropriate clinical setting (i.e., in elderly patients with other symptoms and signs suggestive of GCA). A temporal artery biopsy may be systematically considered in these patients.
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