AI Article Synopsis
- The analysis evaluated reproductive endocrine disorders among 148 women with epilepsy, finding higher rates in those with idiopathic generalized epilepsy compared to control subjects.
- Use of the antiepileptic drug valproate was linked to a greater prevalence of conditions like hyperandrogenism and polycystic ovary syndrome in these women.
- The study concluded that both the type of epilepsy and the use of valproate played significant roles in increasing the risk of reproductive endocrine disorders, particularly when the epilepsy was active early in life.
Article Abstract
The purpose of the analysis described here was to assess reproductive endocrine disorders in 148 women with epilepsy (WWE) by epilepsy type and antiepileptic drug use. Women with idiopathic generalized epilepsy had a higher prevalence of reproductive endocrine disorders than control subjects. In addition, hyperandrogenism, polycystic ovaries, and polycystic ovary syndrome were more prevalent in WWE on valproate than in WWE taking other drugs or control women. The use of VPA was a predictor of the development of polycystic ovaries and polycystic ovary syndrome, and the use of valproate and younger age predicted the development of hyperandrogenism. In conclusion, both idiopathic generalized epilepsy and valproate were associated with an increased risk of reproductive endocrine disorders in WWE in this post hoc reanalysis of data on a large number of WWE. This was especially evident if the epilepsy was active and required treatment early in life.
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| http://dx.doi.org/10.1016/j.yebeh.2006.09.011 | DOI Listing |
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