As phototoxic skin reactions caused by psoralen are induced by wavelengths within the UVA1 spectrum, we assessed the potential of the small amount of psoralen in a normal diet to provoke phototoxicity in volunteers with skin types I and II. Threshold erythema was unaffected by ingestion of a 200-g portion of parsnip.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2006.07.003DOI Listing

Publication Analysis

Top Keywords

dietary furanocoumarin
4
furanocoumarin ingestion
4
ingestion enhance
4
enhance erythemal
4
erythemal response
4
response high-dose
4
high-dose uva1
4
uva1 therapy?
4
therapy? phototoxic
4
phototoxic skin
4

Similar Publications

A total of 11 active ingredients including psoralen, isopsoralen, bakuchiol, bavachalcone, bavachinin, corylin, coryfolin, isobavachalcone, neobavaisoflavone, bakuchalcone, and corylifol A from Psoraleae Fructus in the plasma samples of diabetic and normal rats were simultaneously determined by UHPLC-MS/MS. The pharmacokinetic parameters were calculated to elucidate the pharmacokinetic profiles of coumarins, flavonoids, and monoterpene phenols in normal and diabetic rats. The rat model of type 2 diabetes mellitus(T2DM) was induced by a high-sugar and high-fat diet combined with injection of 1% streptozotocin every two days.

View Article and Find Full Text PDF

Fruits and vegetables serve not only as sources of nutrition but also as medicinal agents for the treatment of diverse diseases and maladies. These dietary components are significant resources of phytochemicals that demonstrate therapeutic properties against many illnesses. Fraxin is a naturally occurring coumarin glycoside mainly present in various species of Fraxinus genera, having a multitude of therapeutic uses against various diseases and disorders.

View Article and Find Full Text PDF
Article Synopsis
  • Diabetic nephropathy (DN) is a big problem for people with diabetes, causing harmful changes in their kidneys because of high blood sugar.
  • A natural compound called Imperatorin (IMP) might help because it can reduce damage and inflammation in kidney cells.
  • In tests on kidney cells and mice with DN, IMP improved kidney health and reduced harmful changes, suggesting it could be a good treatment for DN.
View Article and Find Full Text PDF

Furocoumarins potentiate UVA-induced DNA damage in skin melanocytes.

Biochem Biophys Res Commun

December 2023

Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Channing Division of Network Medicine, Department of Medicine Research, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Epidemiological studies have found that high citrus fruit consumption was associated with higher risk of skin cancer. Citrus fruits and some vegetables contain furocoumarins, which may interact with ultraviolet radiation to induce skin cancer. We aimed to determine the effects of two furocoumarins, including 8-methoxypsoralen (8-MOP) and 6',7'-dihydroxybergamottin (DHB), on UVA-induced DNA damage in human epidermal melanocytes, the origin of melanoma.

View Article and Find Full Text PDF

The aim of this research was to determine oxygen heterocyclic compounds in twenty-six - and cinnamon-flavoured foods using supercritical fluid chromatography in combination with triple-quadrupole mass spectrometry (SFC-QqQ-MS). According to the authors' knowledge, this is the first report on the determination of these molecules in foods by means of the SFC-QqQ-MS technique. The analytical technique normally used for their determination in foods is liquid chromatography coupled with a photodiode array detector.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!