AI Article Synopsis
- Paraneoplastic pemphigus (PNP) is an antibody-mediated mucocutaneous disease primarily found in patients with lymphocytic neoplasms.
- Four patients exhibited clinical features of the lichenoid variant of PNP but did not have detectable autoantibodies.
- This suggests that PNP may also involve cytotoxic T cells in its pathophysiology, indicating a more complex understanding of the disease than previously thought.
Article Abstract
Paraneoplastic pemphigus (PNP) has been described as an antibody-mediated mucocutaneous disease occurring almost exclusively in patients with lymphocytic neoplasms. We describe 4 patients with the clinical features of the lichenoid variant of PNP in the absence of detectable autoantibodies. On the basis of these findings, we conclude that the spectrum of PNP likely includes patients with disease predominantly or exclusively mediated by cytotoxic T cells rather than autoantibodies. The pathophysiology and range of PNP disease are likely more complex than was initially believed.
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| http://dx.doi.org/10.1016/j.jaad.2006.06.007 | DOI Listing |
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