This article describes a method for simultaneous solid-phase synthesis of a quinoxalinone and benzimidazole scaffold library that consists of 240 members. The library was generated by using the solid-phase "split-and-pool" approach and the IRORI sorting system.
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http://dx.doi.org/10.1021/cc060074s | DOI Listing |
Anal Methods
January 2025
Marine Elements and Marine Environment Division, CSIR-Central Salt & Marine Chemicals Research Institute, Bhavnagar 364 002, Gujarat, India.
Monitoring persistent organic pollutants (POPs) with endocrine-disrupting properties poses significant analytical challenges due to labor-intensive, costly, and environmentally unsustainable procedures. This study developed an efficient and robust approach for the simultaneous detection of diverse groups of semi-volatile organics in water and sediment samples using gas chromatography-tandem mass spectrometry (GC-MS). Two extraction methods were studied for determining POPs in water and sediments.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Shenzhen Research Institute of Xiamen University, Shenzhen 518000, China; College of the Environment and Ecology, Xiamen University, Xiamen 361005, China; Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Xiamen 361005, China. Electronic address:
Due to the distinct difference in chemical properties, analysis of organic pollutants and heavy metals generally employs different sample preparation and measurement techniques, resulting in low analytical efficiency and high cost. To this end, a strategy for the co-extraction and then simultaneous quantification of organic pollutants and heavy metals was proposed by the on-line hyphenation of magnetic field-assisted in-tube solid phase microextraction (MA/IT-SPME) and HPLC technique. Simultaneous analysis of triazoles and chromium species were adopted as paradigm to demonstrate the feasibility of the proposed strategy.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Dried blood spot (DBS) assays to quantify novel and repurposed drugs for the treatment of rifampicin-resistant tuberculosis (RR-TB) would facilitate pharmacokinetic studies and therapeutic drug monitoring in low-middle income settings, considering their ease of application and simple sample storage requirements. We describe a DBS method for the simultaneous quantification of bedaquiline and metabolite N-desmethyl bedaquiline, linezolid, levofloxacin, and clofazimine. The analytes were extracted from the matrix and isolated by solid-phase extraction.
View Article and Find Full Text PDFFood Chem
January 2025
School of Public Health, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:
Herein, we report a novel ratiometric nanoprobe (CDs@LZIF-8-Eu) that integrates fluorescent carbon dots (CDs) and Eu on LZIF-8 via a one-pot stirring method. Tetracyclines (TCs) can create inner filter effect on CDs while simultaneously generating an antenna effect with Eu. The rapid and efficient adsorption capabilities of LZIF-8 enhance the probability of TCs interacting with the signal tags.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Savannah River Ecology Laboratory, University of Georgia, Aiken, SC 29802, USA. Electronic address:
The primary approach to assessing monitored natural attenuation (MNA) is currently based on a conceptual model utilizing the total contaminant concentrations, assuming a single aqueous species. However, many contaminants, such as metals and radionuclide - including iodine, can exist in multiple species that behave chemically differently in the environment and can exist simultaneously. For example, radioiodine often occurs concurrently as three major aqueous species: iodide (I), iodate (IO), and organo-I, which undergo distinct attenuation pathways and exhibit markedly different mobility and geochemical behavior.
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