Two series of nine frontal sled tests were conducted to evaluate the behavior of the Hybrid III and Thor-alpha dummies. The first series was conducted at 50 kph with airbag and 4 kN force-limited shoulder belt and the second series at 30 kph and only a 4 kN force-limited shoulder belt. In each series, three replicate tests were conducted with each dummy and compared with three PMHS. The data provided by the same instrumentation located at the same position were compared to assess the biofidelity of both dummies. The results were mass scaled in order to account for the differences between the anthropometry of the cadaver. The good test-to-test repeatability for each dummy permitted to compare the mean value of each recorded parameter. Based on the cadaver response, the results show that the Thor-alpha provides responses that are more similar to those of PMHS than the Hybrid III. The flexible joints in the thoracic spine, the sternum design and the more humanlike ribcage give more similar accelerations than the Hybrid III as compared to those of the PMHS. Nevertheless, some parts have to be improved in order to better follow the behavior of the human subject. The head-neck complex, the chest, the shoulder and the pelvis of the Thor-alpha have a more humanlike behavior but some differences remain. The distribution of the deceleration between the components is sometimes different compared to those of the cadaver, even if the resultants are similar. The dummies and most particularly the Hybrid III are less sensitive to the change in restraint systems and tests conditions than a cadaver.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.4271/2002-22-0001 | DOI Listing |
Arch Pharm (Weinheim)
January 2025
Department of Pharmacognosy, University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.
Alzheimer's disease (AD) is a prevalent neurological illness that affects over 80% of aged adults globally in cases of dementia. Although the exact pathophysiological causes of AD remain unclear, its pathogenesis is primarily driven by several distinct biochemical alterations: (i) the accumulation of toxic Aβ plaques, (ii) the hyperphosphorylation of tau proteins, (iii) oxidative stress resulting in cell death, and (iv) an imbalance between the two main neurotransmitters, glutamate and acetylcholine (ACh). Currently, there are very few medications available and no treatment.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
Department of Chemistry and Chemical Engineering, Taiyuan Institute of Technology, Taiyuan 030008, China.
Cisplatin-based platinum compounds are important clinical chemotherapeutic agents that participate in most tumor chemotherapy regimens. Through density-functional theory calculations, the formation and stability of the inorganic oxide carrier, the mechanisms of the hydrolysis reaction of the activated platinum compound, and its binding mechanism with DNA bases can be studied. The higher the oxidation state of Pt (II to IV), the more electrons transfer from the magnesia-gold composite material to the platinum compound.
View Article and Find Full Text PDFCurr Issues Mol Biol
November 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
In this study, we investigated the regulatory roles of the () gene in the reproductive process of female . Its total cDNA length was 1848 bp, encoding for 460 amino acids. It contained conserved domains typical of epoxide hydrolases, such as the Abhydrolase family domain, the EHN epoxide hydrolase superfamily domain, and the "WWG" and "HGWP" motifs.
View Article and Find Full Text PDFBiosensors (Basel)
December 2024
Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania.
() represents one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. It is a part of the infamous ESKAPE group, which is highly connected with increased rates of healthcare-associated infections and antimicrobial resistance. can cause a large variety of diseases.
View Article and Find Full Text PDFJ Biomed Phys Eng
December 2024
Medical Image and Signal Processing Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: The P300 signal, an endogenous component of event-related potentials, is extracted from an electroencephalography signal and employed in Brain-computer Interface (BCI) devices.
Objective: The current study aimed to address challenges in extracting useful features from P300 components and detecting P300 through a hybrid unsupervised manner based on Convolutional Neural Network (CNN) and Long Short-term Memory (LSTM).
Material And Methods: In this cross-sectional study, CNN as a useful method for the P300 classification task emphasizes spatial characteristics of data.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!