Comparative information about different approaches to treating a disease or condition plays a critical role in the success of any competitive, market-based health care system in achieving quality and value. To ensure that effectiveness studies will be used to stimulate development of important advances in care and not lead to limits in coverage and treatment options, a comparative effectiveness center needs to demonstrate independence from payers; operate with transparent processes; and coordinate, not duplicate, the requirements of the relevant federal agencies. A fully independent, quasi-governmental center is most likely to produce credible, broadly acceptable findings.
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| http://dx.doi.org/10.1377/hlthaff.25.w586 | DOI Listing |
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Alzheimers Dement
December 2024
University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
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Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A., Philadelphia, PA, USA.
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Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, China.
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View Article and Find Full Text PDFBackground: Focused ultrasound (FUS)-induced blood-brain barrier opening (BBBO) is a technique for safely, non-invasively, and transiently opening the blood brain barrier in a targeted area of the brain. Pre-clinical and clinical studies have shown that FUS is capable of decreasing amyloid plaque load and stimulating neurogenesis in Alzheimer's Disease (AD) models, in addition to being safe for use in human patients. However, the effect of FUS-BBBO on neurons has not yet been characterized, despite its crucial role in cognition and regulating brain function.
View Article and Find Full Text PDFDrug Development.
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Imperial College London, London, United Kingdom; Division of Neurology, Department of Brain Sciences, Imperial College London, United Kingdom, London, London, United Kingdom.
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