Nanoparticles for two-photon photodynamic therapy in living cells.

Nano Lett

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

Published: November 2006

We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577608PMC
http://dx.doi.org/10.1021/nl0617179DOI Listing

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