We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360596 | PMC |
| http://dx.doi.org/10.1038/sj.bjc.6603443 | DOI Listing |
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