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Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the concordance of PCR-restriction fragment length polymorphism-derived parasite resistance alleles in matched samples from placenta and circulation was 83 to 98%. Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797640 | PMC |
| http://dx.doi.org/10.1128/AAC.00856-06 | DOI Listing |
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