We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).
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| http://dx.doi.org/10.1016/j.bmcl.2006.10.060 | DOI Listing |
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