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Efficacy and safety of mucolytics in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis.
Respir Investig
November 2024
Department of Environmental Medicine, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku, Kochi, 780-8505, Japan.
Background: The efficacy and safety of mucolytics in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis or exacerbations of COPD have been reported. We conducted a systematic review and meta-analysis of mucolytics in patients with stable COPD.
Methods: Reports from randomized controlled trials to evaluate the efficacy and safety of mucolytics, including ambroxol, bromhexine, carbocisteine, erdosteine, fudosteine, l-methylcysteine, and N-acetylcysteine used in patients with stable COPD were searched for in PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and the Igaku Cyuo Zasshi database.
Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis.
Sleep Breath
August 2024
Department of Pulmonary, Critical Care, and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India, 110029.
Purpose: Obstructive sleep apnea (OSA) is a common clinical problem that is associated with adverse cardiovascular outcomes attributed to the oxidative stress due to sympathetic overstimulation. Treatment approaches targeting oxidative stress have been tried by multiple investigators. This systematic review and meta-analysis evaluated the efficacy and safety of such approaches.
View Article and Find Full Text PDFCase Report: Kawasaki disease associated with acute generalized exanthematous pustulosis secondary to carbocysteine.
Front Pediatr
March 2024
Department of Pediatrics, Yamaguchi-ken Shimonseki Saiseikai General Hospital, Yamaguchi, Japan.
Acute generalized exanthematous pustulosis (AGEP) is an uncommon eruption characterized by sterile pustules on an erythematous background, which is usually associated with drugs. AGEP is described as a self-limiting disease with favorable prognosis. We reported a case of Kawasaki Disease (KD) following AGEP.
View Article and Find Full Text PDFRole of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?
Immunology
July 2024
Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Alterations in airway epithelial homeostasis increase viral respiratory infections risk. Viral infections frequently are associated with chronic obstructive pulmonary disease (COPD) exacerbations, events that dramatically promote disease progression. Mechanism promoting the main respiratory viruses entry and virus-evocated innate and adaptive immune responses have now been elucidated, and an oxidative stress central role in these pathogenic processes has been recognized.
View Article and Find Full Text PDFThe effects of N-acetylcysteine on lung alveolar epithelial cells infected with respiratory syncytial virus.
Malays J Pathol
April 2023
Universiti Kebangsaan Malaysia Medical Centre, Department of Paediatrics, Kuala Lumpur, Malaysia.
Introduction: Respiratory syncytial virus (RSV) is one of the most common causes of acute lower respiratory infection in infants and young children. Mucolytic agents, such as acetylcysteine and carbocysteine have reported benefits in alleviating acute upper or lower respiratory infections. Among these, N-acetylcysteine (NAC) has cyto-protective effects when cells are infected with the RSV.
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