Objective: To investigate the association of lipoprotein receptor-related protein 5 (LRP5) gene Q89R, A1330V polymorphism with bone mineral density (BMD) in premenopausal Northern Chinese women.
Methods: 283 unrelated healthy residents of Han nationality in Harbin, aged 20 - 50, were selected. All subjects completed a food frequency questionnaire administered by a trained dietitian to estimate dietary calcium intakes, and were measured values of biochemical and hormone, such as the level of serum calcium, serum phosphorus, alkaline phosphatase, parathyroid hormone, calcitonin, 25 (OH) D3, 1, 25 (OH)2D3. The BMD phenotypes were measured by dual energy X-ray densitometry. The polymorphisms of LRP5 gene were determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
Results: Frequencies of LRP5 genotype QQ, QR, AA and AV were 83.4%, 16.6%, 64.3% and 35.7% in all subjects. It failed to find that the values of serum biochemistry and the levels of hormones were statistically different among genotypes. Stepwise multiple regression analysis showed that the strongest predictor for BMD was body weight, other significant predictors were age and LRP5 genotypes, A1330V polymorphism were associated with BMD at lumbar spine, however Q89R polymorphism were associated with BMD at shaft and total hip (P = 0.033 and 0.034 respectively).
Conclusion: LRP gene polymorphism was predictor for BMD in Northern Chinese premenopausal women, BMD at various were modified by different genetic and lifestyle factors in female.
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