Objective: The aim of this study was to examine the clinical and histopathologic effects of pentoxifylline on psoriasis, compared with placebo.
Methods: Sixty-one outpatients with active psoriasis were randomly assigned to either of 2 groups: one was given pentoxifylline 400 mg tid PO, and the other, placebo. Fifty-six patients concluded the study. They were evaluated clinically and by laboratory parameters before and after 8 weeks of treatment. Pretreatment and posttreatment biopsies were taken. Initial sections were stained with hematoxylin-eosin. Further cuts were immunostained for cytokeratins 10, 14, and 16.
Results: Clinical and histologic improvement did not show statistically significant differences between the groups. No laboratory abnormalities or serious reactions related to the drug were observed.
Conclusions: No statistical difference was seen when the treatment group was compared with the control group. Pentoxifylline is a well tolerated and safe drug, but its efficacy in psoriasis appears to be limited.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1540-9740.2006.05681.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison.
BMC Med Imaging
January 2025
Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tomography (CT), MRI, and PET/CT) in a full head-to-head manner.
View Article and Find Full Text PDFSolitary Fibrous Tumor of the Tongue: a Case Report.
Head Neck Pathol
January 2025
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areão, Piracicaba, São Paulo, Brazil.
Introduction: Solitary fibrous tumor (SFT) is a fibroblastic neoplasm of uncertain biological origin that is rare in the tongue.
Case Report: A 42-year-old woman presented with a painless, submucosal nodule in the tongue. Based on the clinical hypothesis of benign mesenchymal neoplasia, the lesion was excised, and the specimen was submitted for histopathological analysis.
Dan-Shen-Yin against ethanol-induced chronic gastric mucosal injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
J Ethnopharmacol
January 2025
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, P. R. China; Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China. Electronic address:
Ethnopharmacological Relevance: The pathogenesis of alcoholic gastric injury has long been a significant topic in the medical field. Dan-Shen-Yin (DSY), a classic traditional Chinese medicine formula, has been shown to alleviate gastric mucosal injury and to treat stomachaches in clinical settings. However, the mechanism by which DSY against alcoholic gastric injury requires further investigation.
View Article and Find Full Text PDFTherapeutic potential of bioactive peptides against Lactococcus petauri in Nile tilapia.
Microb Pathog
January 2025
São Paulo State University (UNESP), Aquaculture Center of UNESP, Laboratory of Microbiology and Parasitology of Aquatic Organisms, Jaboticabal, São Paulo, Brazil, 14.884-900; Graduate Program in Agricultural and Livestock Microbiology, São Paulo State University (UNESP), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil, 14884-900. Electronic address:
Lactococcus petauri is an emerging pathogen causing piscine lactococcosis in various aquatic species. This disease has been increasingly reported as a cause of mortality in aquaculture. Due to the indiscriminate use of antimicrobials and to promote viable alternatives for their replacement, bioactive peptides with antimicrobial properties can be explored as tools against bacterial infections.
View Article and Find Full Text PDFMulti-omic Sequencing of Intermediate to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.
J Invest Dermatol
January 2025
Mayo Clinic Arizona, Department of Dermatology, Scottsdale, AZ. Electronic address:
Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in humans and kills as many people annually as melanoma. The understanding of the transcriptional changes with respect to high-risk clinical/histopathological features and outcome is poor. Here, we examine stage-matched, outcome-differentiated cSCC using whole exome and transcriptome sequencing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!