AI Article Synopsis
- The study aimed to compare three non-invasive techniques for assessing endothelial function in adults and children during acute inflammation.
- Flow-mediated dilation (FMD) is established as a reliable method but is costly and complex, while pulse wave analysis (PWA) and pulse contour analysis (PCA) may be simpler alternatives.
- Results show that FMD is the most reproducible method for measuring vascular dysfunction, particularly during inflammation, whereas PCA's high variability makes it unsuitable for regular use in children.
Article Abstract
Objectives: The purpose of this study was to compare 3 non-invasive techniques for assessment of endothelial function in adults and children and evaluate their utility in acute inflammation.
Background: Endothelial dysfunction is a key early event in pre-clinical atherosclerosis. Flow-mediated dilation (FMD), although the established technique, is expensive and technically demanding. Measurements of vascular responses to inhaled salbutamol by pulse wave analysis (PWA) or pulse contour analysis (PCA) are potential alternatives.
Methods: Sixteen adults (mean age 28 years, range 18 to 39) and 16 children (mean age 13 years, range 7 to 17) underwent concurrent vascular function testing on 2 occasions with ultrasound, PWA, and PCA. Eighteen men were also studied before and after typhoid vaccination.
Results: Reproducibility of FMD was high in adults and children (coefficient of variation [CV] = 7.1 and 6.3, respectively). Salbutamol responses were more variable with PWA (adults CV = 11.5, children CV = 17.1) and PCA particularly in children (adults CV = 18.2, children CV = 36.3). Flow-mediated dilation (p < 0.001) and PWA with salbutamol (p = 0.03) responses fell after typhoid vaccination, and PCA (p = 0.7) was unchanged.
Conclusions: Vascular dysfunction during acute inflammation can be measured by FMD and by PWA with salbutamol. Flow-mediated dilation is less variable than PWA. Variability of PCA makes this technique currently unsuited to serial measures of endothelial function in children. Flow-mediated dilation remains the most reproducible method.
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| http://dx.doi.org/10.1016/j.jacc.2006.07.039 | DOI Listing |
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