Several diseases may be confused with scabies. Atypical manifestations of scabies have previously been reported, including urticaria, contact dermatitis, and dermatitis herpetiformis. There are also reports of scabies mimicking bullous pemphigoid. Here we report a case of scabies in a patient with manifestation similar to bullous pemphigoid. Direct smear of the bullous lesions was performed and was positive for scabies mites. The skin biopsy specimens submitted for light microscopy and direct immunofluorescence study were considered to be compatible with bullous pemphigoid. The patient treated with single dose oral ivermectin and prednisolone. The pruritus subsided and the eruption improved dramatically in 2 weeks.

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Relationship between bullous pemphigoid and metabolic syndrome and its relevant traits: a bidirectional two-sample Mendelian randomization study.

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January 2025

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, No.1 Shuai Fu Yuan Street, Dong Cheng District, Beijing, 100730, China.

Article Synopsis
  • Bullous pemphigoid (BP) is a chronic autoimmune blistering disease primarily affecting older adults, while metabolic syndrome (MetS) encompasses various metabolic disorders.
  • Previous observational studies have suggested a link between BP and MetS, but the results are inconsistent due to potential biases from confounding factors like corticosteroid use or age.
  • This study utilized Mendelian randomization (MR) to explore the causal relationship between BP and MetS, using genetic data, and found no significant causal association between the two or their related traits.
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