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The genetic relationships between immune cell traits, circulating inflammatory proteins and preeclampsia/eclampsia.
Front Immunol
June 2024
Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Guangzhou, Guangdong, China.
Objectives: Preeclampsia/eclampsia (PE), a critical complication during pregnancy, has been suggested to correlate with immune cell phenotypes and levels of circulating inflammatory proteins. Our study aimed to employ a two-sample mendelian randomization (MR) analysis to assess the potential causal effects of immune cell phenotypes and circulating inflammatory proteins on the onset of PE.
Methods: We utilized summary-level data from genome-wide association studies (GWAS).
Sympathetic Neurofunction Testing in Gestational Hypertension and Relationship with Developing Preeclampsia and Eclampsia: Real-world Evidences from Clinical Pharmacology Clinics.
J Assoc Physicians India
March 2024
Senior Endocrinologist, Department of Endocrinology, Joshi Clinic, Mumbai, Maharashtra, India.
Article Synopsis
- Gestational hypertension poses risks for both mothers and babies, potentially leading to conditions like preeclampsia; this study investigates sympathetic nervous system function in affected women.
- The study included 52 women with pregnancy-induced hypertension and 52 without, assessing their blood pressure responses to exercise to determine differences in autonomic function.
- Results indicated significantly higher blood pressure responses in the hypertensive group, suggesting that the increased sympathetic activity is linked to a higher risk of developing preeclampsia or eclampsia, highlighting a potential area for new treatments.
Preeclampsia epidemiology(ies) and pathophysiology(ies).
Best Pract Res Clin Obstet Gynaecol
June 2024
Obstetrics Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research University of Pittsburgh, 10 Georgian Place, Pittsburgh, PA, 15215, United States. Electronic address:
Preeclampsia/eclampsia was first described 2000 years ago. Concepts guiding diagnosis have changed over time making longitudinal studies challenging. Similarly, concepts of pathophysiology have evolved from eclampsia as a pregnancy seizure disorder to preeclampsia as a hypertensive and renal disorder to our current concept of a preeclampsia as a pregnancy specific, multisystemic inflammatory disorder.
View Article and Find Full Text PDFFirst-trimester preterm preeclampsia prediction model for prevention with low-dose aspirin.
J Obstet Gynaecol Res
May 2024
CRIFM Prenatal Medical Clinic, Osaka, Japan.
Introduction: Preeclampsia (PE) is a major maternal and fetal threat. Previous risk-scoring methods in guidelines lacked precision. The Fetal Medicine Foundation (FMF) proposed a first-trimester PE screening model using Bayes' theorem.
View Article and Find Full Text PDFOccupational physical activity as a determinant of daytime activity patterns and pregnancy and infant health.
PLoS One
December 2023
Department of Epidemiology and Biostatistics, West Virginia University, Morgantown, West Virginia, United States of America.
Article Synopsis
- The study investigated how occupational physical activity (OPA) and sedentary behavior (SB) during pregnancy influence overall physical activity patterns and health outcomes for both mothers and infants.
- Researchers analyzed data from two cohorts, identifying four distinct groups based on participants' OPA patterns: sitting, part-time mixed, active, and non-working.
- While significant variations in daily physical activity were observed among the groups, there were no notable differences in adverse pregnancy outcomes or infant health indicators across these groups.
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