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High altitude pulmonary oedema: Mimicker of acute coronary syndrome.
Med J Armed Forces India
December 2024
Clinical Tutor, Department of Internal Medicine, Armed Forces Medical College, C/o 56 APO, India.
High altitude pulmonary oedema (HAPO) is a common emergency seen at high altitude. It can be associated with electrocardiogram (ECG) changes due to pulmonary arterial hypertension in the form of ST elevation and T wave inversion in the right precordial leads, which mimic acute coronary syndrome. These changes can lead to confusion in diagnosis and management.
View Article and Find Full Text PDFIdentification of potential biomarkers and pathways involved in high-altitude pulmonary edema using GC-MS and LC-MS metabolomic methods.
Sci Rep
December 2024
Department of Intensive Care Unit, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, China.
High-altitude pulmonary edema (HAPE) is a life-threatening altitude sickness afflicting certain individuals after rapid ascent to high altitude above 2500 m. In the setting of HAPE, an early diagnosis is critical and currently based on clinical evaluation. The aim of this study was to utilize the metabolomics to identify the altered metabolic patterns and potential biomarkers for HAPE.
View Article and Find Full Text PDFEffect of age on lung adaptation to high-altitude hypoxia in Tibetan sheep.
Front Vet Sci
December 2024
Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
After prolonged adaptation to high-altitude environments, Tibetan sheep have developed a robust capacity to withstand hypobaric hypoxia. Compared to low-altitude sheep, various organs and tissues in Tibetan sheep have undergone significant adaptive remodeling, particularly in the lungs. However, whether lambs and adult Tibetan sheep exhibit similar adaptations to high-altitude hypoxia remains unclear.
View Article and Find Full Text PDFHigh Altitude is an Independent Risk Factor for Postoperative Venous Thromboembolism Following Primary Total Knee Arthroplasty: A Large Database Study.
J Arthroplasty
December 2024
Orthopaedic Foundation, Stamford, CT.
Introduction: Venous thromboembolism (VTE) is a relatively uncommon but potentially fatal complication following total knee arthroplasty (TKA). High altitude may induce physiological changes that can predispose patients to VTE. The purpose of this study was to determine if high altitude is an independent risk factor for postoperative VTE following TKA.
View Article and Find Full Text PDFA stable rat model of high altitude pulmonary edema established by hypobaric hypoxia combined diurnal temperature fluctuation and exercise.
Biochem Biophys Res Commun
December 2024
Department of Pharmacy, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, 730050, People's Republic of China; Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China. Electronic address:
Hypobaric hypoxia (HH) is regarded as the main cause of high-altitude pulmonary edema (HAPE), however, the effect of diurnal temperature fluctuation and exercise has been overlooked. The aim of current study was to elucidate the role of diurnal temperature fluctuation and exercise in the development of HAPE and establish a reliable experimental rat model. Male SPF Wistar rats were assigned to control group (1400 m, 25 °C) and five model groups: Model Ⅰ group (6000 m, 25 °C), Model Ⅱ group (6000 m, 2 °C), Model Ⅲ group (6000 m, 12 °C/2 °C light/dark cycle), Model IV group (6000 m, 2 °C, and exercise) and Model V group (6000 m, 12 °C/2 °C light/dark cycle, and exercise).
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