Corneal topographic features in a family with nanophthalmos.

Purpose: To characterize the corneal topographic features in a family with nanophthalmos.

Methods: Two observational case reports and a review of the literature. Corneal shape was analyzed using a topographic modeling system (TMS) and an Orbscan topographic system, with further analysis based on Fourier series and Zernicke polynomials. A control group was used for comparison.

Results: Two female family members with nanophthalmos belonging to the same generation showed significant irregular corneal astigmatism and corneal steepening.

Conclusion: Topographic corneal steepening and irregular astigmatism seems to be associated in 1 family with inherited nanophthalmos. Higher degrees of irregular astigmatism, which were not evident without a topographic analysis, may account, in part, for the unexplained visual reduction.