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Introduction: Hemodialysis patients need long-term frequent use of parenteral anticoagulants, and the side effects need to be taken seriously. This study aimed to assess the reporting of adverse drug reactions (ADRs) following administration of unfractionated heparin (UFH), low molecular weight heparins (LMWHs), fondaparinux, and danaparoid, in relation to their usage in European Economic Area (EEA).
Materials And Methods: The total number of ADRs of each anticoagulant between 2017 to 2021 was collected using data from the EudraVigilance database.
Anticoagulation approach in morbid obesity: a comprehensive review on venous thromboembolism management.
Front Pharmacol
December 2024
2nd Internal Medicine Department, Sf. Spiridon Clinical Emergency Hospital, Iasi, Romania.
Article Synopsis
- Obesity is a significant risk factor for venous thromboembolism (VTE) and poses unique challenges in anticoagulation management due to limited research on how extreme body weight affects medication outcomes.
- This review focuses on patients with a body mass index (BMI) of 40 kg/m² or higher, analyzing various anticoagulants' dosages, efficacy, and safety for both prevention and treatment of VTE.
- The study emphasizes the need for personalized treatment strategies and careful monitoring, especially for specific groups like cancer patients or those with kidney issues, given the insufficient evidence available for effective anticoagulant therapy in morbidly obese individuals.
A cluster of pediatric vaccine-induced immune thrombotic thrombocytopenia-like cases with thrombosis and thrombocytopenia following respiratory infections-case series.
Res Pract Thromb Haemost
October 2024
Haemophilia Centre for Children and Adolescents/Haemostasis and Thrombosis Unit, "Aghia Sofia" Children's Hospital, Athens, Greece.
Background: Adenoviral vector COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) is a heparin-independent platelet-activating disorder. An increasing number of VITT-like disorders without previous vaccination are being identified.
Key Clinical Question: To explore the association of the pediatric cluster of postinfectious thrombosis and thrombocytopenia with VITT-like disorders.
Management of Acute Pulmonary Embolism: A Review.
J Assoc Physicians India
November 2024
Consultant and Head, Department of Cardiology, Safdarjung Hospital, Delhi, India.
Article Synopsis
- Pulmonary embolism (PE) is a significant health concern in India, often missed or poorly managed, leading to increased risk of cardiovascular issues in hospitalized patients.
- Current research and studies have improved understanding of PE diagnosis, assessment, and treatment strategies, emphasizing the need for risk stratification of patients based on mortality risk.
- Recommended treatments include the use of anticoagulants and thrombolytics, with oral anticoagulants like warfarin and newer options (NOACs) being preferred for their ease of use and effectiveness at the time of diagnosis.
Real world application of the 2023 ACR/EULAR antiphospholipid antibody syndrome classification criteria in a pharmacist directed anticoagulation clinic.
Lupus
January 2025
Department of Pharmacy, Upstate University Hospital, Syracuse, NY, USA.
Article Synopsis
- - The study aimed to assess how many patients with antiphospholipid antibody syndrome (APS) met the new 2023 ACR/EULAR classification criteria and to explore reasons for those who did not qualify.
- - A review of 51 patient records revealed that only 12 (23.5%) met the classification criteria, while 33 (64.7%) did not, with various reasons cited including failure to meet laboratory or clinical standards.
- - Findings suggest APS diagnosis and classification are complex, highlighting a need for further evaluation and management strategies for the small number of patients who still fit the new criteria.
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