ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.

Beilstein J Org Chem

Pfizer Global R&D, Department of Medicinal Chemistry, 10614 Science Center Drive, San Diego, CA 92121, USA.

Published: October 2006

A series of pyridine ether PPAR agonists were synthesized through an ADDP and PS-PPh3 modified Mitsunobu protocol, which eliminated significant by-product formation. This method proved to be versatile, efficient and amenable to parallel synthesis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705810PMC
http://dx.doi.org/10.1186/1860-5397-2-21DOI Listing

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