AI Article Synopsis
- A new series of kynurenic acid amides were created that are derived from ring-enlarged indole-2-carboxamides.
- These compounds are specifically active as NMDA receptor antagonists that target the NR2B subtype.
- The text details the process of synthesizing these compounds and explores their structure-activity relationships (SAR).
Article Abstract
A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed.
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| http://dx.doi.org/10.1016/j.bmcl.2006.10.033 | DOI Listing |
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