Posterior cortical atrophy is a striking clinical syndrome in which a dementing illness begins with visual symptoms. Initially, the problem may seem to be loss of elementary vision, but over time the patient develops features of visual agnosia, topographical difficulty, optic ataxia, simultanagnosia, ocular apraxia (Balint's syndrome), alexia, acalculia, right-left confusion, and agraphia (Gerstmann's syndrome), and later a more generalized dementia. Occasional patients have visual hallucinations and signs of Parkinson's disease or Lewy body dementia. A number of different neuropathologic disorders are associated with posterior cortical atrophy.
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http://dx.doi.org/10.1007/s11910-006-0049-0 | DOI Listing |
Lens tension is essential for accommodative vision but remains challenging to measure with precision. Here, we present an optical coherence elastography (OCE) technique that quantifies both the tension and elastic modulus of lens tissue and capsule. This method derives mechanical parameters from surface wave dispersion across a critical frequency range of 1-30 kHz.
View Article and Find Full Text PDFIn sensory and mid-level regions of the brain, stimulus information is often topographically organized; functional responses are arranged in maps according to features such as retinal coordinates, auditory pitch, and object animacy or size. However, such organization is typically measured during stimulus input, e.g.
View Article and Find Full Text PDFSci Rep
January 2025
Women's Operational Military Exposure Network Center of Excellence (WOMEN COE), VA Palo Alto Health Care System, Palo Alto, USA.
Anhedonia, a core symptom of depression, has been defined as the loss of pleasure or lack of reactivity to pleasurable stimuli. Considering the relevance of alpha asymmetry to MDD and anhedonia, we explored the effect of dorsolateral prefrontal cortex (DLPFC) stimulation on frontal and posterior EEG alpha asymmetry (FAA and PAA, respectively), in this exploratory investigation. 61 participants randomly received sham (n = 11), bilateral (BS; n = 25), or unilateral stimulation (US; n = 25) of the DLPFC.
View Article and Find Full Text PDFBehav Brain Res
January 2025
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, Ghent, Belgium. Electronic address:
Working memory is crucial for daily life and is often impaired in neuropsychiatric conditions. Attempts to enhance it using transcranial direct current stimulation (tDCS) have shown mixed results, possibly due to large inter-individual variability. This study assessed whether baseline regional brain volume was associated with working memory performance following tDCS.
View Article and Find Full Text PDFSchizophr Bull
January 2025
Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China.
Background And Hypothesis: Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized morphological brain network approaches have emerged recently. We hypothesize that individualized morphological brain networks are disrupted in schizophrenia.
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