Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.

World J Gastroenterol

Department of Surgery, Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China.

Published: October 2006

Aim: To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation.

Methods: Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique.

Results: Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05).

Conclusion: IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088135PMC
http://dx.doi.org/10.3748/wjg.v12.i39.6285DOI Listing

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