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A novel biomarker of COVI-19: MMP8 emerged by integrated bulk RNAseq and single-cell sequencing.
Sci Rep
December 2024
Department of Rehabilitative medicine, Shaanxi Provincial People's Hospital, No.256, Youyi West Road, Beilin District, Xi'an, 710068, Shaanxi, China.
COVID-19 has been emerging as the most influential illness which has caused great costs to the heath of population and social economy. Sivelestat sodium (SS) is indicated as an effective cure for lung dysfunction, a characteristic symptom of COVID-19 infection, but its pharmacological target is still unclear. Therefore, a deep understanding of the pathological progression and molecular alteration is an urgent issue for settling the diagnosis and therapy problems of COVID-19.
View Article and Find Full Text PDFSivelestat sodium alleviated sepsis-induced acute lung injury by inhibiting TGF-β/Smad signaling pathways through upregulating microRNA-744-5p.
J Thorac Dis
October 2024
Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Intensive Care Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Background: Acute lung injury (ALI) is one of the most common critical illnesses in clinical practice, with sepsis being the most common cause of ALI. Sivelestat sodium (SV) hydrate is a highly effective inhibitor of neutrophil elastase, specifically targeting ALI related to systemic inflammatory response syndrome. The aim of this study is to examine the mechanisms by which SV can reduce the severity of ALI resulting from sepsis.
View Article and Find Full Text PDFSivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice.
Drug Des Devel Ther
October 2024
Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People's Republic of China.
Purpose: We aim to detect the effects of sivelestat on renal ischemia-reperfusion associated with AKI and also explore the underlying mechanism.
Materials And Methods: Mice, aged between 8 and 12 weeks, were randomly allocated among four distinct groups, respectively normal saline sham group(C), normal saline surgery group(I), sivelestat (50 mg/kg) sham group(S), sivelestat (50 mg/kg) surgery group(SI) (n=6, each group). In the surgical groups, the renal pedicles of mice were clamped with non-traumatic micro-aneurysm clamps, resulting in ischemia of the kidneys for 45 minutes.
In vitro atomization analysis and evaluation of inhalable sodium sivelestat formulations.
PLoS One
September 2024
Jinan University, College of Pharmcy, Guangzhou, China.
Article Synopsis
- The paper investigates the in vitro atomization properties of a self-developed sodium sivelestat for inhalation to assess its potential as an aerosol medication and to inform future animal studies.
- It analyzes atomization performance by measuring fine particle mass and total emitted dose, confirming that it meets inhalation requirements.
- The study compares two nebulizers (air compressed and mesh), finding that mesh nebulizers produce smaller and more uniform particles, and concludes that inhalation of sodium sivelestat is equally effective as its injection form in treating lung injury in mice.
[Sivelestat sodium inhibits neutrophil elastase to regulate intrahepatic biliary mucin 5AC expression].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
June 2024
Department of Hepatobiliary Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China. Corresponding author: Li Jiang, Email:
Objective: To explore whether sivelestat sodium could reduce the expression of mucin 5AC (MUC5AC) in intrahepatic bile duct epithelial cells by inhibiting neutrophil elastase (NE) and thus provide new potential therapeutic ideas for the treatment of intrahepatic bile duct stone (IBDS).
Methods: (1) Bioinformatics analysis: differential gene analysis was performed on gallbladder stone cholecystitis sequencing data based on the gene expression omnibus (GEO) to screen for significantly different genes related to neutrophils and mucins. The search tool for the retrieval of interacting genes database (STRING) was used for protein interaction analysis to predict whether there was an interaction between NE and MUC5AC genes.
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