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Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium. | LitMetric

Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium.

Pflugers Arch

Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, 4217, Australia.

Published: January 2007

AI Article Synopsis

Article Abstract

There is mixed evidence adenosine receptors (ARs) may enhance myocardial contractility, although this remains contentious. We assessed inotropic actions of adenosine (50 muM) and selective AR activation with 100 nM N (6)-cyclohexyladenosine (CHA; A(1)AR agonist), 25 nM 2-[p-(2-carboxyethyl) phenethylamino]-5'-N-ethylcarboxamidoadenosine (CGS-21680; A(2A)AR agonist) and 100 nM 2-chloro-N (6)-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA; A(3)AR agonist) in mouse hearts perfused at constant pressure, constant flow, or conditions of stable flow and pressure (following maximal nitroprusside-mediated dilatation at constant flow). Adenosine and CGS-21680 significantly (although modestly) increased force in constant-pressure perfused hearts (

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Source
http://dx.doi.org/10.1007/s00424-006-0119-9DOI Listing

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